Historique
Article de Périodique
Synthetic cannabinoids in e-liquids: A proton and fluorine NMR analysis from a conventional spectrometer to a compact one (2021)
Auteur(s) :
WU, N. ;
DANOUN, S. ;
BALAYSSAC, S. ;
MALET-MARTINO, M. ;
LAMOUREUX, C. ;
GILARD, V.
Année
2021
Page(s) :
art. 110813
Langue(s) :
Anglais
Refs biblio. :
49
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ANALYSE CHIMIQUE
;
CANNABINOIDES
;
DROGUES DE SYNTHESE
;
E-CIGARETTE
;
METHODE
;
MESURES QUALITATIVES
;
MESURES QUANTITATIVES
;
TOXICOLOGIE
Thésaurus géographique
FRANCE
Résumé :
The 1H NMR profiles of 13 samples of e-liquids supplied by French customs were obtained with high-field and low-field NMR. The high-field 1H NMR spectra allowed the detection of matrix signals, synthetic cannabinoids, and flavouring compounds. Quantitative results were obtained for the five synthetic cannabinoids detected: JWH-210, 5F-MDMB-PICA, 5F-ADB, 5F-AKB48, and ADB-FUBINACA. Conventional GC-MS analysis was used to confirm compound identification. Fluorine-19 NMR was proposed for the quantification of fluorinated synthetic cannabinoids and was successfully implemented on both 400 MHz and 60 MHz NMR spectrometers. This study based on few examples explored the potentiality of low-field NMR for quantitative and quantitative analysis of synthetic cannabinoids in e-liquids.
Highlights:
• NMR was applied to the analysis of e-liquids containing synthetic cannabinoids.
• The 1H NMR profiles of 13 samples of e-liquids were obtained with HF and LF NMR.
• Fluorinated synthetic cannabinoids were quantified using HF and LF 19F NMR.
• Quantitative results were obtained for the five synthetic cannabinoids detected.
Highlights:
• NMR was applied to the analysis of e-liquids containing synthetic cannabinoids.
• The 1H NMR profiles of 13 samples of e-liquids were obtained with HF and LF NMR.
• Fluorinated synthetic cannabinoids were quantified using HF and LF 19F NMR.
• Quantitative results were obtained for the five synthetic cannabinoids detected.
Affiliation :
Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, Toulouse, France
SCL, Laboratoire de Paris, Massy, France
SCL, Laboratoire de Paris, Massy, France