Historique
Article de Périodique
HCV-related mortality among HIV/HCV co-infected patients: The importance of behaviors in the HCV cure era (ANRS CO13 HEPAVIH Cohort) (2020)
Auteur(s) :
SANTOS, M. E. ;
PROTOPOPESCU, C. ;
SOGNI, P. ;
YAYA, I. ;
PIROTH, L. ;
BAILLY, F. ;
MARCELLIN, F. ;
ESTERLE, L. ;
WITTKOP, L. ;
ROSENTHAL, E. ;
MORLAT, P. ;
ROUX, P. ;
DE ARAUJO, W. N. ;
SALMON-CERON, D. ;
CARRIERI, M. P. ;
ANRS CO13-HEPAVIH Study Group
Année
2020
Page(s) :
1069-1084
Langue(s) :
Anglais
Refs biblio. :
52
Domaine :
Alcool / Alcohol ; Drogues illicites / Illicit drugs ; Tabac / Tobacco / e-cigarette
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Résumé :
Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray's competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10-0.83], 0.38 [0.15-0.95], and 0.28 [0.10-0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00-5.93] and 7.25 [2.22-23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10-4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.
Affiliation :
INSERM, IRD, SESSTIM, Sciences Economiques, & Sociales de la Santé & Traitement de l'Information Médicale, Aix Marseille Université, Marseille, France