Historique
Article de Périodique
A case report of carfentanil-related fatality in France (2019)
Auteur(s) :
GAULIER, J. M. ;
RICHEVAL, C. ;
PHANITHAVONG, M. ;
BRAULT, S. ;
ALLORGE, D. ;
DUMESTRE-TOULET, V.
Année
2019
Page(s) :
323-331
Sous-type de document :
Etude de cas / Case report
Langue(s) :
Anglais
Refs biblio. :
58
Domaine :
Autres substances / Other substances
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
FRANCE
Thésaurus mots-clés
ETUDE DE CAS
;
FENTANYL
;
MORTALITE
;
ANALYSE CHIMIQUE
;
MEDECINE LEGALE
;
TOXICOLOGIE
;
METABOLITE
Résumé :
Today, NPS are increasingly being related to post-mortem cases, and this problem drastically intensifies as a result of the New Synthetic Opioids (NSOs) surge. Among NSOs, carfentanil (CaF) is the most potent fentanyl analogue and was central to a large number of NSOs-related fatalities in North America, as well as in UE, since 2016. In this worrisome context, this manuscript reports the first CaF-related fatality occurred in France. A 41-years-old man was found dead with a syringe planted under his tongue. This man has a psychiatric follow-up for opiate addiction and his recent medical history included intoxication with fentanyl derivatives. Toxicological investigations of post-mortem samples (blood, urine and hair), and syringe were requested. CaF (with several other psychoactive drugs at non-toxic level) was detected in biological samples and in syringe residue using LC-HRMS, and quantified using LC-MS/MS in blood, urine and hair (from proximal to distal hair section - 3cm length each) at 4.20, 0.40 µg/L and 54/114/166 pg/mg, respectively. The relatively high post-mortem CaF blood concentration together with the absence of metabolite (especially NorCaF) suggests a sudden death of the victim immediately following a significant CaF dose intake (presumably injected) that can explain the decease.
Affiliation :
Unité fonctionnelle de toxicologie, CHU de Lille, Lille, France
Cote :
Abonnement