Historique
Article de Périodique
Cannabis addiction and the brain: A review (2018)
Auteur(s) :
ZEHRA, A. ;
BURNS, J. ;
LIU, C. K. ;
MANZA, P. ;
WIERS, C. E. ;
VOLKOW, N. D. ;
WANG, G. J.
Année
2018
Page(s) :
438-452
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CERVEAU
;
CANNABIS
;
NEUROBIOLOGIE
;
MECANISME D'ACTION
;
INTOXICATION
;
SYNDROME DE SEVRAGE
;
RENFORCEMENT
;
ADDICTION
;
COGNITION
;
PHYSIOLOGIE
;
IMAGERIE MEDICALE
Résumé :
Cannabis is the most commonly used substance of abuse in the United States after alcohol and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a decrease in the perceived risk of cannabis use, it is imperative to assess the addictive potential of cannabis. Here we evaluate cannabis use through the neurobiological model of addiction proposed by Koob and Volkow. The model proposes that repeated substance abuse drives neurobiological changes in the brain that can be separated into three distinct stages, each of which perpetuates the cycle of addiction. Here we review previous research on the acute and long-term effects of cannabis use on the brain and behavior, and find that the three-stage framework of addiction applies to CUD in a manner similar to other drugs of abuse, albeit with some slight differences. These findings highlight the urgent need to conduct research that elucidates specific neurobiological changes associated with CUD in humans.
Affiliation :
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA