Historique
Article de Périodique
Attempt of scopolamine-facilitated robbery: an original case of poisoning by inhalation confirmed by LC-MS/MS and review of the literature (2020)
Auteur(s) :
DUFAYET, L. ;
ALCARAZ, E. ;
DOROL, J. ;
REY-SALMON, C. ;
ALVAREZ, J. C.
Année
2020
Page(s) :
264-268
Sous-type de document :
Etude de cas / Case report ; Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
26
Domaine :
Autres substances / Other substances
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ALCALOIDES HALLUCINOGENES
;
SOUMISSION CHIMIQUE
;
ANALYSE CHIMIQUE
;
INHALATION
;
DELIT
;
TOXICOLOGIE
Thésaurus géographique
FRANCE
Résumé :
Purpose: Scopolamine, an alkaloid found in certain plants, has become a drug of use for recreational and predatory purposes. We present here the case of an attempted scopolamine-facilitated robbery, via inhalation, with full recovery of the victim. We also performed a review of toxicological findings for scopolamine poisoning cases in available scientific literature.
Methods: Whole blood and urine samples were collected 4h after the assumed poisoning. Concentrations of scopolamine were determined in both samples by a validated and accredited method using liquid chromatography–tandem mass spectrometry.
Results: Scopolamine was the only substance found in both whole blood and urine samples, at 7 and 510 ng/mL, respectively.
Conclusions: Scopolamine poisoning remains rare, as its half-life is short; blood and urine should be collected as soon as possible for toxicological analysis. This case is, to our knowledge, the first described case of inhaled scopolamine robbery attempt, with quantitative toxicological findings.
Methods: Whole blood and urine samples were collected 4h after the assumed poisoning. Concentrations of scopolamine were determined in both samples by a validated and accredited method using liquid chromatography–tandem mass spectrometry.
Results: Scopolamine was the only substance found in both whole blood and urine samples, at 7 and 510 ng/mL, respectively.
Conclusions: Scopolamine poisoning remains rare, as its half-life is short; blood and urine should be collected as soon as possible for toxicological analysis. This case is, to our knowledge, the first described case of inhaled scopolamine robbery attempt, with quantitative toxicological findings.
Affiliation :
Unité Médico-Judiciaire, Hôtel Dieu APHP, Paris, France