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Article de Périodique
How the complex pharmacology of the fentanyls contributes to their lethality [Editorial] (2019)
Auteur(s) :
GILL, H. ;
KELLY, E. ;
HENDERSON, G.
Année
2019
Page(s) :
1524-1525
Sous-type de document :
Editorial
Langue(s) :
Anglais
Refs biblio. :
19
Domaine :
Autres substances / Other substances
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Résumé :
Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to high potency and rapid onset of respiratory depression, these drugs also induce respiratory muscle stiffness, making it more difficult to breathe, are less sensitive than heroin to naloxone reversal and may show reduced cross-tolerance to other opioids.
Affiliation :
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK
Cote :
Abonnement