Historique
Article de Périodique
Management of opioid use disorder in the USA: present status and future directions (2019)
Auteur(s) :
BLANCO, C. ;
VOLKOW, N. D.
Année
2019
Page(s) :
1760-1772
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
148
Domaine :
Autres substances / Other substances
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
OPIOIDES
;
PRISE EN CHARGE
;
COMORBIDITE
;
DEPISTAGE
;
SEVRAGE
;
TRAITEMENT
;
PHARMACOTHERAPIE
;
TRAITEMENT DE MAINTENANCE
;
EFFICACITE
;
SURDOSE
;
RECHERCHE
Résumé :
Opioid use disorder is characterised by the persistent use of opioids despite the adverse consequences of its use. The disorder is associated with a range of mental and general medical comorbid disorders, and with increased mortality. Although genetics are important in opioid use disorder, younger age, male sex, and lower educational attainment level and income, increase the risk of opioid use disorder, as do certain psychiatric disorders (eg, other substance use disorders and mood disorders). The medications for opioid use disorder, which include methadone, buprenorphine, and extended-release naltrexone, significantly improve opioid use disorder outcomes. However, the effectiveness of medications for opioid use disorder is limited by problems at all levels of the care cascade, including diagnosis, entry into treatment, and retention in treatment. There is an urgent need for expanding the use of medications for opioid use disorder, including training of health-care professionals in the treatment and prevention of opioid use disorder, and for development of alternative medications and new models of care to expand capabilities for personalised interventions.
Affiliation :
National Institute on Drug Abuse, Bethesda, MD, USA