Historique
Article de Périodique
How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review (2019)
Auteur(s) :
HOCH, E. ;
NIEMANN, D. ;
VON KELLER, R. ;
SCHNEIDER, M. ;
FRIEMEL, C. M. ;
PREUSS, U. W. ;
HASAN, A. ;
POGARELL, O.
Année
2019
Page(s) :
87-105
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
93
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
CANNABIS
;
USAGE THERAPEUTIQUE
;
EFFICACITE
;
PSYCHOPATHOLOGIE
;
CANNABINOIDES
;
DEMENCE
;
PSYCHOSE
;
ANOREXIE
;
TROUBLES DU COMPORTEMENT
;
SCHIZOPHRENIE
;
INTERVENTION
;
DEPENDANCE
;
OPIOIDES
Résumé :
We conducted a review of systematic reviews (SRs) and randomized-controlled trials (RCTs) to analyze efficacy and safety of cannabis-based medication in patients with mental disorders. Five data bases were systematically searched (2006-August 2018); 4 SRs (of 11 RCTs) and 14 RCTs (1629 participants) were included. Diagnoses were: dementia, cannabis and opioid dependence, psychoses/schizophrenia, general social anxiety, posttraumatic stress disorder, anorexia nervosa, attention-deficit hyperactivity disorder, and Tourette`s disorder. Outcome variables were too heterogeneous to conduct a meta-analysis. A narrative synthesis method was applied. The study quality was assessed using the risk-of-bias tool and SIGN-checklists. THC- and CBD-based medicines, given as adjunct to pharmaco- and psychotherapy, were associated with improvements of several symptoms of mental disorders, but not with remission. Side effects occurred, but severe adverse effects were mentioned in single cases only. In order to provide reliable treatment recommendations, more and larger RCTs with follow-up assessments, consistent outcome measures and active comparisons are needed.
Affiliation :
Cannabinoid Research and Treatment Group, Department of Psychiatry and Psychotherapy, University Hospital, LMU, Munich, Germany