Historique
Article de Périodique
Higher average potency across the United States is associated with progression to first cannabis use disorder symptom (2019)
Auteur(s) :
ARTERBERRY, B. J. ;
TRELOAR PADOVANO, H. ;
FOSTER, K. T. ;
ZUCKER, R. A. ;
HICKS, B. M.
Année
2019
Page(s) :
186-192
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
CANNABIS
;
TETRAHYDROCANNABINOL
;
SYMPTOME
;
ETUDE LONGITUDINALE
;
FACTEUR PREDICTIF
;
FACTEUR DE RISQUE
;
TYPE D'USAGE
Résumé :
Objective: To determine if higher potency cannabis is associated with earlier progression to regular cannabis use, daily cannabis use, and cannabis use disorder symptom onset.
Methods: Data sources were the Michigan Longitudinal Study, an ongoing prospective, high-risk family study investigating the course and predictors for substance use disorders among youth beginning prior to school entry and time-parallel national average trends in delta-9-tetrahydrocannabinol (i.e., psychoactive compound in cannabis). The national average trends in delta-9-tetrahydrocannabinol were used to estimate potency level for the individual. Only cannabis users were included in analyses (n = 527).
Results: Cox regression showed an increased risk of progression from cannabis initiation to cannabis use disorder symptom onset by 1.41 times (p < .001) for each unit increase in national average delta-9-tetrahydrocannabinol as compared to those not endorsing CUD symptom onset, adjusting for sex, regular use, and cohort effects. Accounting for regular use, individuals initiating cannabis at national average 4.9% delta-9-tetrahydrocannabinol were at 1.88 times (p = .012) higher risk for cannabis use disorder symptom onset within one year compared to those who did not endorse CUD symptom onset, while those initiating cannabis at national average 12.3% delta-9-tetrahydrocannabinol were at 4.85 times (p = .012) higher risk within one year.
Conclusions: This study provides prospective evidence suggesting higher potency cannabis, on average in the U.S., increases risk for onset of first cannabis use disorder symptom. Development of guidelines regarding cannabis potency is critical for reducing the costs associated with negative health outcomes.
Highlights:
Risk to faster cannabis use disorder symptom onset increased at higher potency levels.
Initiating at 4.9% showed 88% risk for symptom onset within a year.
Initiating at 12.3% showed 4.85 times higher risk for symptom onset within a year.
Potency did not predict progression to regular or daily cannabis use.
Methods: Data sources were the Michigan Longitudinal Study, an ongoing prospective, high-risk family study investigating the course and predictors for substance use disorders among youth beginning prior to school entry and time-parallel national average trends in delta-9-tetrahydrocannabinol (i.e., psychoactive compound in cannabis). The national average trends in delta-9-tetrahydrocannabinol were used to estimate potency level for the individual. Only cannabis users were included in analyses (n = 527).
Results: Cox regression showed an increased risk of progression from cannabis initiation to cannabis use disorder symptom onset by 1.41 times (p < .001) for each unit increase in national average delta-9-tetrahydrocannabinol as compared to those not endorsing CUD symptom onset, adjusting for sex, regular use, and cohort effects. Accounting for regular use, individuals initiating cannabis at national average 4.9% delta-9-tetrahydrocannabinol were at 1.88 times (p = .012) higher risk for cannabis use disorder symptom onset within one year compared to those who did not endorse CUD symptom onset, while those initiating cannabis at national average 12.3% delta-9-tetrahydrocannabinol were at 4.85 times (p = .012) higher risk within one year.
Conclusions: This study provides prospective evidence suggesting higher potency cannabis, on average in the U.S., increases risk for onset of first cannabis use disorder symptom. Development of guidelines regarding cannabis potency is critical for reducing the costs associated with negative health outcomes.
Highlights:
Risk to faster cannabis use disorder symptom onset increased at higher potency levels.
Initiating at 4.9% showed 88% risk for symptom onset within a year.
Initiating at 12.3% showed 4.85 times higher risk for symptom onset within a year.
Potency did not predict progression to regular or daily cannabis use.
Affiliation :
Department of Psychology, Iowa State University, Ames, IA, USA