Historique
Article de Périodique
Cannabinoid concentrations in blood and urine after smoking cannabidiol joints (2018)
Auteur(s) :
MEIER, U. ;
DUSSY, F. ;
SCHEURER, E. ;
MERCER-CHALMERS-BENDER, K. ;
HANGARTNER, S.
Année
2018
Page(s) :
62-67
Langue(s) :
Anglais
Refs biblio. :
18
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
SUISSE
Thésaurus mots-clés
CANNABIDIOL
;
ANALYSE CHIMIQUE
;
CANNABINOIDES
;
DEPISTAGE
;
CONDUITE DE VEHICULE
;
SANG
;
URINE
;
COMPARAISON
;
ABSTINENCE
;
TOXICOLOGIE
;
TETRAHYDROCANNABINOL
;
ETUDE DE CAS
Résumé :
ENGLISH:
In Switzerland, the sale of cannabis with tetrahydrocannabinol (THC) content less than 1% has recently been legalized. As a consequence, cannabis with low THC and high cannabidiol (CBD) values up to approximately 25% is legally available on the market. In this study, we investigated cannabinoid blood and urine concentrations of a naive user and of a modeled chronic user after smoking a single CBD joint. Chronic use was modeled as smoking 2 joints per day for 10 days. Joints contained 200mg of cannabis with THC concentrations of 0.94% and 0.8% and CBD concentrations of 23.5% and 17% in the naive-smoker and chronic-smoker experiment, respectively. After smoking, blood and urine samples were collected for 4 and 20h after smoking start, respectively. THC blood concentrations reached 2.7 and 4.5ng/mL in the naive and chronic user, respectively. In both cases, the blood THC concentration is significantly above the Swiss road traffic threshold of 1.5ng/mL. Consequently, the user was legally unfit to drive directly after smoking. CBD blood concentrations of 45.7 and 82.6ng/mL were reached for the naive and chronic user, respectively. During the 10-day smoking period, blood and urine samples were regularly collected. No accumulation of any cannabinoid was found in the blood during this time. Urinary 11-nor-9-carboxy-THC concentrations seemed to increase during the 10-day period, which is important in abstinence testing.
Highlights:
Blood/urine concentrations after use of CBD rich/THC low cannabis were investigated.
Blood THC concentrations exceeded the Swiss Road Traffic Act threshold of 1.5 ng/mL.
THC-COOH accumulation in urine is suspected.
FRANÇAIS :
En Suisse, le cannabis avec une teneur en THC inférieure à 1 % et un taux élevé en CBD est de plus en plus populaire. Les chercheurs ont analysé les concentrations de CBD et de THC dans le sang après un usage unique et une semaine d'utilisation quotidienne de 0,2 gramme de cannabis avec des concentrations de THC entre 0,94 % et 0,8 % et des concentrations de CBD entre 23,5 % et 17 %. Après 4 heures, la concentration de THC dans le sang atteignait entre 2,7 et 4,5 ng/mL après un usage unique et hebdomadaire et entre 45,7 et 82,6 ng/mL pour la concentration de CBD. [IACM, 12/09/2018]
In Switzerland, the sale of cannabis with tetrahydrocannabinol (THC) content less than 1% has recently been legalized. As a consequence, cannabis with low THC and high cannabidiol (CBD) values up to approximately 25% is legally available on the market. In this study, we investigated cannabinoid blood and urine concentrations of a naive user and of a modeled chronic user after smoking a single CBD joint. Chronic use was modeled as smoking 2 joints per day for 10 days. Joints contained 200mg of cannabis with THC concentrations of 0.94% and 0.8% and CBD concentrations of 23.5% and 17% in the naive-smoker and chronic-smoker experiment, respectively. After smoking, blood and urine samples were collected for 4 and 20h after smoking start, respectively. THC blood concentrations reached 2.7 and 4.5ng/mL in the naive and chronic user, respectively. In both cases, the blood THC concentration is significantly above the Swiss road traffic threshold of 1.5ng/mL. Consequently, the user was legally unfit to drive directly after smoking. CBD blood concentrations of 45.7 and 82.6ng/mL were reached for the naive and chronic user, respectively. During the 10-day smoking period, blood and urine samples were regularly collected. No accumulation of any cannabinoid was found in the blood during this time. Urinary 11-nor-9-carboxy-THC concentrations seemed to increase during the 10-day period, which is important in abstinence testing.
Highlights:
Blood/urine concentrations after use of CBD rich/THC low cannabis were investigated.
Blood THC concentrations exceeded the Swiss Road Traffic Act threshold of 1.5 ng/mL.
THC-COOH accumulation in urine is suspected.
FRANÇAIS :
En Suisse, le cannabis avec une teneur en THC inférieure à 1 % et un taux élevé en CBD est de plus en plus populaire. Les chercheurs ont analysé les concentrations de CBD et de THC dans le sang après un usage unique et une semaine d'utilisation quotidienne de 0,2 gramme de cannabis avec des concentrations de THC entre 0,94 % et 0,8 % et des concentrations de CBD entre 23,5 % et 17 %. Après 4 heures, la concentration de THC dans le sang atteignait entre 2,7 et 4,5 ng/mL après un usage unique et hebdomadaire et entre 45,7 et 82,6 ng/mL pour la concentration de CBD. [IACM, 12/09/2018]
Affiliation :
Institute of Forensic Medicine of the University of Basel, Health Department Basel-Stadt, Basel, Switzerland