Historique
Article de Périodique
Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis (2018)
Auteur(s) :
MUSTONEN, A. ;
NIEMELA, S. ;
NORDSTROM, T. ;
MURRAY, G. K. ;
MAKI, P. ;
JAASKELAINEN, E. ;
MIETTUNEN, J.
Année
2018
Page(s) :
227-233
Langue(s) :
Anglais
Refs biblio. :
28
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus géographique
FINLANDE
Thésaurus mots-clés
COHORTE
;
ADOLESCENT
;
CANNABIS
;
PSYCHOSE
;
FACTEUR DE RISQUE
;
SYMPTOME
;
ETUDE PROSPECTIVE
;
PSYCHOPATHOLOGIE
Résumé :
Background: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.
Aims: To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.
Method: The sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15-16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.
Results: The risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0-13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1-8.0).
Conclusions: Adolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.
Declaration of interest: None.
Aims: To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.
Method: The sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15-16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.
Results: The risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0-13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1-8.0).
Conclusions: Adolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.
Declaration of interest: None.
Affiliation :
Center for Life Course Health Research, University of Oulu, Oulu, Finland