Historique
Article de Périodique
Feasibility and preliminary effectiveness of varenicline for treating co-occurring cannabis and tobacco use (2018)
Auteur(s) :
ADAMS, T. R. ;
ARNSTEN, J. H. ;
NING, Y. M. ;
NAHVI, S.
Année
2018
Page(s) :
12-18
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs ; Tabac / Tobacco / e-cigarette
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
TABAC
;
CANNABIS
;
TRAITEMENT
;
POLYCONSOMMATION
;
VARENICLINE
;
EFFICACITE
;
PHARMACOTHERAPIE
;
ETUDE CLINIQUE
Résumé :
Few studies have evaluated treatment for co-occurring cannabis and tobacco use. The objective of this pilot study was to evaluate the feasibility and preliminary effectiveness of varenicline for co-occurring cannabis and tobacco use. Participants who reported cannabis use on >=5 days per week were recruited from an urban, outpatient opioid treatment program (OTP). Participants were randomized to either four weeks of standard OTP clinical care (SCC; medication-assisted treatment for opioid use disorder and individual behavioral counseling), followed by four weeks of SCC plus varenicline (SCC+VT), or to four weeks of SCC+VT followed by four weeks of SCC. All participants contributed feasibility and outcome data during both study phases. Of 193 persons screened, seven were enrolled. Retention at eight weeks was 100%. No adverse effects prompted varenicline discontinuation. Participants reported lower cannabis craving during the SCC+VT phase compared to baseline, and lower frequencies and quantities of cannabis use compared to both baseline and the SCC alone phase. In the SCC+VT phase, participants also reported fewer cigarettes per day. Among persons with co-occurring cannabis and tobacco use, varenicline is well-tolerated and may reduce cannabis craving, cannabis use, and tobacco use.
Affiliation :
Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA
Cote :
Abonnement