Historique
Article de Périodique
Meta-analysis of the association between the level of cannabis use and risk of psychosis (2016)
Auteur(s) :
MARCONI, A. ;
DI FORTI, M. ;
LEWIS, C. M. ;
MURRAY, R. M. ;
VASSOS, E.
Année
2016
Page(s) :
1262-1269
Sous-type de document :
Méta-analyse / Meta-analysis
Langue(s) :
Anglais
Refs biblio. :
40
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
FACTEUR DE RISQUE
;
PSYCHOSE
;
SCHIZOPHRENIE
;
DOSE-REPONSE
Résumé :
ENGLISH:
Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response relationship has been observed. We performed a systematic review of studies that investigate the association between the degree of cannabis consumption and psychosis and a meta-analysis to quantify the magnitude of effect. Published studies were identified through search of electronic databases, supplemented by manual searches of bibliographies. Studies were considered if they provided data on cannabis consumption prior to the onset of psychosis using a dose criterion (frequency/amount used) and reported psychosis-related outcomes. We performed random effects meta-analysis of individual data points generated with a simulation method from the summary data of the original studies. From 571 references, 18 studies fulfilled inclusion criteria for the systematic review and 10 were inserted in the meta-analysis, enrolling a total of 66 816 individuals. Higher levels of cannabis use were associated with increased risk for psychosis in all the included studies. A logistic regression model gave an OR of 3.90 (95% CI 2.84 to 5.34) for the risk of schizophrenia and other psychosis-related outcomes among the heaviest cannabis users compared to the nonusers. Current evidence shows that high levels of cannabis use increase the risk of psychotic outcomes and confirms a dose-response relationship between the level of use and the risk for psychosis. Although a causal link cannot be unequivocally established, there is sufficient evidence to justify harm reduction prevention programs.
FRANÇAIS :
Une méta-analyse incluant 10 études et un total de 66 816 gros consommateurs de cannabis a associé cette consommation à un risque accru de psychose. Ce résultat est présent dans toutes les études. L'étude indique un pourcentage de 3,90 pour le risque de schizophrénie et de troubles d'ordre psychiatrique pour les très gros consommateurs comparés aux non-consommateurs. Les auteurs ont écrit qu'un lien causal ne peut être établi explicitement. [IACM, 02/03/2016]
Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response relationship has been observed. We performed a systematic review of studies that investigate the association between the degree of cannabis consumption and psychosis and a meta-analysis to quantify the magnitude of effect. Published studies were identified through search of electronic databases, supplemented by manual searches of bibliographies. Studies were considered if they provided data on cannabis consumption prior to the onset of psychosis using a dose criterion (frequency/amount used) and reported psychosis-related outcomes. We performed random effects meta-analysis of individual data points generated with a simulation method from the summary data of the original studies. From 571 references, 18 studies fulfilled inclusion criteria for the systematic review and 10 were inserted in the meta-analysis, enrolling a total of 66 816 individuals. Higher levels of cannabis use were associated with increased risk for psychosis in all the included studies. A logistic regression model gave an OR of 3.90 (95% CI 2.84 to 5.34) for the risk of schizophrenia and other psychosis-related outcomes among the heaviest cannabis users compared to the nonusers. Current evidence shows that high levels of cannabis use increase the risk of psychotic outcomes and confirms a dose-response relationship between the level of use and the risk for psychosis. Although a causal link cannot be unequivocally established, there is sufficient evidence to justify harm reduction prevention programs.
FRANÇAIS :
Une méta-analyse incluant 10 études et un total de 66 816 gros consommateurs de cannabis a associé cette consommation à un risque accru de psychose. Ce résultat est présent dans toutes les études. L'étude indique un pourcentage de 3,90 pour le risque de schizophrénie et de troubles d'ordre psychiatrique pour les très gros consommateurs comparés aux non-consommateurs. Les auteurs ont écrit qu'un lien causal ne peut être établi explicitement. [IACM, 02/03/2016]
Affiliation :
Department of Psychosis Studies, King's College London, Institute of Psychiatry Psychology & Neuroscience, London, UK