Historique
Article de Périodique
Fenetylline: New results on pharmacology, metabolism and kinetics (1986)
Auteur(s) :
NICKEL, B. ;
NIEBCH, G. ;
PETER, G. ;
VON SCHLICHTEGROLL, A. ;
TIBES, U. ;
Committee on Problems of Drug Dependence Symposium on Stimulants and Hallucinogens (June-September 1984)
Année
1986
Page(s) :
235-257
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
PHARMACOLOGIE
;
METABOLISME
;
AMPHETAMINE
;
MODELE ANIMAL
;
STIMULANTS
;
ANOREXIGENES
;
MECANISME D'ACTION
;
PHARMACOCINETIQUE
Note générale :
Fenetylline = 7-[2'-(alpha-methylphenethylamino)-ethyl]-theophylline = Captagon®
Résumé :
In the fenetylline molecule, theophylline is covalently linked with amphetamine via an alkyl chain. The inclusion of amphetamine and results from early metabolic studies have led to speculation that fenetylline may be merely a prodrug for amphetamine and/or theophylline. Although previous studies are not consistent with this hypothesis, additional studies were conducted to comparatively evaluate the profiles of activity exhibited by fenetylline and its two postulated primary metabolites, (±)-amphetamine and theophylline. Investigations were also initiated using newly developed high pressure liquid chromatography (HPLC) techniques to further characterize the metabolic pattern that fenetylline undergoes and to examine the relationship between plasma pharmacokinetics and the pharmacodynamic actions of the drug.
Fenetylline inhibits activity associated with amphetamine in certain test systems, an effect similar to that previously observed with fenfluramine. Only small amounts of the amphetamine theoretically available in the fenetylline molecule are released.
Pharmacodynamic activity associated with fenetylline administration is more closely tied to plasma levels of the parent compound than to any (±)-amphetamine produced.
Fenetylline inhibits activity associated with amphetamine in certain test systems, an effect similar to that previously observed with fenfluramine. Only small amounts of the amphetamine theoretically available in the fenetylline molecule are released.
Pharmacodynamic activity associated with fenetylline administration is more closely tied to plasma levels of the parent compound than to any (±)-amphetamine produced.
Affiliation :
Degussa Pharma Gruppe, Chemiewerk Homburg, Frankfurt Main, Germany
Cote :
Abonnement