Historique
Article de Périodique
Fatal intoxications with 25B-NBOMe and 25I-NBOMe in Indiana during 2014 (2015)
Auteur(s) :
SHANKS, K. G. ;
SOZIO, T. ;
BEHONICK, G. S.
Année
2015
Page(s) :
602-606
Sous-type de document :
Etude de cas / Case report
Langue(s) :
Anglais
Refs biblio. :
17
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
INTOXICATION
;
MORTALITE
;
DROGUES DE SYNTHESE
;
ANALYSE CHIMIQUE
;
TOXICOLOGIE
;
AUTOPSIE
;
ETUDE DE CAS
Résumé :
Over the last few years, NBOMe substances have been used either as a legal alternative to lysergic acid diethylamide (LSD) or sold surreptitiously as LSD to unknown users. These NBOMe substances have been detected in blotter papers, powders, capsules and liquids. We report the deaths of two teenage male subjects that were related to 25B-NBOMe and 25I-NBOMe in Indiana during 2014. Samples were extracted via a solvent protein precipitation with acetonitrile and analyzed via ultra-performance liquid chromatography with tandem mass spectrometry. For these two cases, we describe the NBOMe instrumental analysis, toxicological results for postmortem heart blood and urine specimens and the relevant case history and pathological findings at autopsy. In the first case, 25B-NBOMe was detected in postmortem heart blood at 1.59 ng/mL; in the second case, 25I-NBOMe was detected in postmortem heart blood at 19.8 ng/mL. We also review relevant published casework from clinical toxicology and postmortem toxicology in which analytically confirmed 25B-NBOMe and 25I-NBOMe were determined to be causative agents in intoxications or deaths.
Affiliation :
AIT Laboratories, Indianapolis, IN, USA