Historique
Article de Périodique
Report of five cases of 2,5-dimethoxy-4-(n)-propylphenethylamine (2C-P) intoxication following recreational use (2015)
Auteur(s) :
BRETAUDEAU DEGUIGNE, M. ;
FÉREC, S. ;
LELIÈVRE, B. ;
BRUNEAU, C. ;
DIQUET, B. ;
HARRY, P. ;
TURCANT, A.
Année
2015
Page(s) :
99-104
Sous-type de document :
Etude de cas
Langue(s) :
Anglais
Refs biblio. :
19
Domaine :
Drogues illicites
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
FRANCE
Thésaurus mots-clés
ETUDE DE CAS
;
DROGUES DE SYNTHESE
;
USAGE RECREATIF
;
INTOXICATION
;
TOXICOLOGIE
;
ANALYSE CHIMIQUE
Résumé :
Introduction: 2,5-dimethoxy-4-(n)-propylphenethylamine-P (2C-P) is a synthetic derivative belonging to the new so-called 2C-series family of phenethylamine recreational drugs. The exact mechanism of 2C compounds is unknown, but they show affinity for the 5-HT2 serotoninergic receptors. We report on the toxicological analysis findings on five cases of exposure to 2C-P.
Case-series: The five cases involved five men aged from 17 to 21 years old. They ingested 2C-P (powder or liquid form) in a festive setting. Their major symptoms were mydriasis, severe agitation, confusion, visual hallucinations, sinus tachycardia and high blood pressure. The outcome was favourable for the five patients.
Methods: For the five patients, toxicological analyses of blood and urine samples obtained on admission were performed using both GC-MS and HPLC-DAD. Specific 2C-P assays were performed by HPLC-DAD and UPLC-MS/MS.
Results: Toxicological analysis identified 2C-P as the main active substance in urines of all five cases and in the plasma of only one case (20 µg/L).
Conclusion: Our results showed that 2C-P was active at very low levels. Clinicians should be alert to this substance and they should confirm exposure by blood and urine analysis.
Case-series: The five cases involved five men aged from 17 to 21 years old. They ingested 2C-P (powder or liquid form) in a festive setting. Their major symptoms were mydriasis, severe agitation, confusion, visual hallucinations, sinus tachycardia and high blood pressure. The outcome was favourable for the five patients.
Methods: For the five patients, toxicological analyses of blood and urine samples obtained on admission were performed using both GC-MS and HPLC-DAD. Specific 2C-P assays were performed by HPLC-DAD and UPLC-MS/MS.
Results: Toxicological analysis identified 2C-P as the main active substance in urines of all five cases and in the plasma of only one case (20 µg/L).
Conclusion: Our results showed that 2C-P was active at very low levels. Clinicians should be alert to this substance and they should confirm exposure by blood and urine analysis.
Affiliation :
Centre antipoison toxicovigilance Grand Ouest, CHU d'Angers, Angers, France
Cote :
Abonnement