Historique
Article de Périodique
Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB) (2014)
Auteur(s) :
ADAMOWICZ, P. ;
ZUBA, D. ;
BYRSKA, B.
Année
2014
Page(s) :
126-132
Sous-type de document :
Etude de cas / Case report
Langue(s) :
Anglais
Refs biblio. :
39
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
POLOGNE
Thésaurus mots-clés
ETUDE DE CAS
;
INTOXICATION
;
MORTALITE
;
DROGUES DE SYNTHESE
;
TOXICOLOGIE
;
SYMPTOME
;
ANALYSE CHIMIQUE
Résumé :
The emergence of a large number of new psychoactive substances (NPSs) in recent years poses a serious problem to clinical and forensic toxicologists. Here we report a patient who administrated ca. 500 mg of 3-MMC (3-methyl-N-methylcathinone) and 400 mg of 5-APB (5-(2-aminopropyl)benzofuran) in combination with 80 g of ethyl alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. The patient did not recover and died around 4 h after the use of drugs. The cause of death was acute cardiovascular collapse that occurred following mixed intoxication with NPSs and alcohol. Toxicological analysis of post-mortem blood revealed 3-MMC and 5-APB in concentrations of 1.6 μg/mL and 5.6 μg/mL, respectively. Moreover, the serum alcohol concentration was 1.4 g/L in ante-mortem sample collected 1 h after admission to the hospital. This is the first report on blood concentration of 3-MMC and 5-APB in fatal intoxication.
Highlights:
We report a fatal case of 3-MMC and 5-APB poisoning in combination with alcohol.
The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia.
Results of toxicological analysis were as follows: 1.6 μg/mL for 3-MMC, 5.6 μg/mL for 5-APB and 1.4 g/L for alcohol.
Developed methods allow distinguishing between 3-MMC and 4-MMC as well as 5-APB and 6-ABP.
Highlights:
We report a fatal case of 3-MMC and 5-APB poisoning in combination with alcohol.
The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia.
Results of toxicological analysis were as follows: 1.6 μg/mL for 3-MMC, 5.6 μg/mL for 5-APB and 1.4 g/L for alcohol.
Developed methods allow distinguishing between 3-MMC and 4-MMC as well as 5-APB and 6-ABP.
Affiliation :
Institute of Forensic Research, Krakow, Poland