Historique
Article de Périodique
Acute combined poisoning with the new designer drug 4-methyl-N-ethyl-cathinone (4-MEC) and gammabutyrolactone (GBL): A case report with different analytical approaches for identification of some metabolites (2014)
Auteur(s) :
TURCANT, A. ;
BOELS, D. ;
HELFER, A. G. ;
FÉREC, S. ;
BRETAUDEAU DEGUIGNE, M. ;
LELIÈVRE, B. ;
MEYER, M. R. ;
MAURER, H. H.
Année
2014
Page(s) :
119-127
Sous-type de document :
Etude de cas / Case report
Langue(s) :
Anglais
Refs biblio. :
20
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
FRANCE
Thésaurus mots-clés
ETUDE DE CAS
;
INTOXICATION
;
CATHINONES
;
DROGUES DE SYNTHESE
;
GBL
;
METABOLITE
;
ANALYSE CHIMIQUE
;
TOXICOLOGIE
Note générale :
Erratum: Toxicologie Analytique et Clinique, 2015:27(3), p. 212.
Résumé :
Objective: 4-Methyl-N-ethylcathinone (4-MEC) is a novel designer drug of the beta-keto amphetamine family. A case of a mixed poisoning by 4-MEC and gamma-butyrolactone (GBL) is described. Two and half hours after an injected 0.25-0.5 g 4-MEC dose and thirty minutes after GBL ingestion, a 39-year-old man became unconscious and presented after admission to the hospital, transient apnea needing oxygenation and stimulation. After 30 min, he woke up, but remained confused for 4 hours. He was discharged 13 hours later without particular symptoms. For confirmation of the poisoning, different analytical procedures such as HPLC-UV/DAD, GC-MS, UPLC-MS/MS, and LC-HR-MS/MS were applied. Blood and urine levels (8 h after injection) were respectively 353 µg/L and 100 mg/L for 4-MEC and 300 mg/L and 1000 mg/L for gamma-hydroxybutyric acid. In urine, three metabolites (dihydro-, nor-, and nor-dihydro-4-MEC) could be identified for the first time and were similar to those described for other molecules of this class.
Affiliation :
Laboratoire de pharmacologie-toxicologie, Institut de biologie en santé, Centre hospitalier universitaire, Angers, France