Historique
Article de Périodique
Bath salts and synthetic cathinones: An emerging designer drug phenomenon (2014)
Auteur(s) :
GERMAN, C. L. ;
FLECKENSTEIN, A. E. ;
HANSON, G. R.
Année
2014
Page(s) :
2-8
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
DROGUES DE SYNTHESE
;
CATHINONES
;
PHENOMENE EMERGENT
;
MEPHEDRONE
;
METHYLONE
;
TOXICOLOGIE
;
CHIMIE
;
EFFET RECHERCHE
;
MECANISME D'ACTION
Résumé :
Synthetic cathinones are an emerging class of designer drugs abused for psychostimulant and hallucinogenic effects similar to cocaine, methylenedioxymethamphetamine (MDMA), or other amphetamines. Abuse of synthetic cathinones, frequently included in products sold as ‘bath salts’, became prevalent in early 2009, leading to legislative classification throughout Europe in 2010 and schedule I classification within the United States in 2011. Recent pre-clinical and clinical studies indicate that dysregulation of central monoamine systems is a principal mechanism of synthetic cathinone action and presumably underlie the behavioral effects and abuse liability associated with these drugs. This review provides insight into the development of synthetic cathinones as substances of abuse, current patterns of their abuse, known mechanisms of their action and toxicology, and the benefits and drawbacks of their classification.
Affiliation :
Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT, USA