Historique
Article de Périodique
From the street to the laboratory: analytical profiles of methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their determination in three biological matrices (2013)
Auteur(s) :
DE PAOLI, G. ;
BRANDT, S. D. ;
WALLACH, J. ;
ARCHER, R. P. ;
POUNDER, D. J.
Année
2013
Page(s) :
277-283
Langue(s) :
Anglais
Refs biblio. :
32
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ANALYSE CHIMIQUE
;
DROGUES DE SYNTHESE
;
PHENCYCLIDINE
;
METHODE
;
URINE
;
SANG
;
DEPISTAGE
Résumé :
Three psychoactive arylcyclohexylamines, advertised as "research chemicals", were obtained from an online retailer and characterized by gas chromatography ion trap electron and chemical ionization mass spectrometry, nuclear magnetic resonance spectroscopy and diode array detection. The three phencyclidines were identified as 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexanone (methoxetamine), N-ethyl-1-(3-methoxyphenyl)cyclohexanamine and 1-[1-(3-methoxyphenyl)cyclohexyl]piperidine. A qualitative/quantitative method of analysis was developed and validated using liquid chromatography (HPLC) electrospray tandem mass spectrometry and ultraviolet (UV) detection for the determination of these compounds in blood, urine and vitreous humor. HPLC–UV proved to be a robust, accurate and precise method for the qualitative and quantitative analysis of these substances in biological fluids (0.16–5.0 mg/L), whereas the mass spectrometer was useful as a confirmatory tool.
Affiliation :
Centre for Forensic and Legal Medicine, University of Dundee, Dundee, UK
Cote :
A00998