Historique
Article de Périodique
Cocaine intoxication (2012)
Auteur(s) :
ZIMMERMAN, J. L.
Année
2012
Page(s) :
517-526
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
61
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
VOIE D'ADMINISTRATION
;
EFFET SECONDAIRE
;
INTOXICATION
;
PHARMACOLOGIE
;
PHYSIOLOGIE
;
SYSTEME NERVEUX CENTRAL
;
APPAREIL CARDIOVASCULAIRE
;
APPAREIL RESPIRATOIRE
;
SYMPTOME
;
TOXICITE
Résumé :
Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Among the most severe complications are seizures, hemorrhagic and ischemic strokes, myocardial infarction, aortic dissection, rhabdomyolysis, mesenteric ischemia, acute renal injury and multiple organ failure.
Affiliation :
Department of Medicine, Weill Cornell Medical College, New York, NY, USA