Historique
Article de Périodique
Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers (2012)
Auteur(s) :
RIGAL, L. ;
ALEXANDRE-DUBROEUCQ, C. ;
DE BEAUREPAIRE, R. ;
LE JEUNNE, C. ;
JAURY, P.
Année
2012
Page(s) :
439-442
Langue(s) :
Anglais
Refs biblio. :
17
Domaine :
Alcool / Alcohol
Thésaurus mots-clés
BACLOFENE
;
ETUDE RETROSPECTIVE
;
TRAITEMENT DE MAINTENANCE
;
ALCOOL
;
DEPENDANCE
;
ABSTINENCE
;
CONSOMMATION
;
EFFET SECONDAIRE
;
POSOLOGIE
;
EFFICACITE
Thésaurus géographique
FRANCE
Résumé :
AIMS: The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen.
METHODS: This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
RESULTS: Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
CONCLUSION: High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers.
METHODS: This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
RESULTS: Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
CONCLUSION: High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers.
Affiliation :
Département de Médecine Générale, Faculté de Médecine Paris Descartes—Site Cochin, Université Paris Descartes, Paris, France