Historique
Article de Périodique
Comparison of Acetorphan with Clonidine for opiate withdrawal symptoms (1991)
Auteur(s) :
HARTMANN, F. ;
POIRIER, M. F. ;
BOURDEL, M. C. ;
LOO, H. ;
LECOMTE, J. M. ;
SCHWARTZ, J. C.
Année
1991
Page(s) :
627-629
Langue(s) :
Anglais
Refs biblio. :
13
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Thésaurus mots-clés
PRODUIT DE SUBSTITUTION
;
TRAITEMENT DE MAINTENANCE
;
CLONIDINE
;
ETUDE RANDOMISEE
;
SYNDROME DE SEVRAGE
Résumé :
OBJECTIVE AND METHOD: The authors compared the effects of acetorphan, an enkephalinase inhibitor, with those of clonidine for the treatment of the opioid withdrawal syndrome. Nineteen patients addicted to heroin or synthetic opiates who were undergoing drug withdrawal and displayed a withdrawal syndrome according to DSM-III criteria were studied for 5 days in a hospital setting. In a double-blind trial, 10 subjects were given acetorphan intravenously and nine were given clonidine; objective signs and subjective symptoms of withdrawal were recorded. RESULTS: On several objective signs, the effect of acetorphan was more marked than that of clonidine, whereas the two drugs exhibited similar efficacy with respect to the subjective components of withdrawal. No side effect was noted in the subjects who received acetorphan. CONCLUSIONS: Enkephalinase inhibition may constitute a novel and safe therapeutic approach to the opioid withdrawal syndrome.
Affiliation :
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Centre Hospitalier Sainte-Anne, Paris, France
Cote :
A04152