Historique
Article de Périodique
Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity (2012)
Auteur(s) :
SCHINDLER, C. W. ;
GOLDBERG, S. R.
Année
2012
Page(s) :
163-175
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
92
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
TOXICITE
;
TRAITEMENT
;
METABOLISME
;
PHARMACOLOGIE
;
PHARMACOCINETIQUE
;
ENZYMES
;
ANTICORPS
;
RECHERCHE
Résumé :
One pharmacokinetic approach to the treatment of cocaine abuse and toxicity involves the development of compounds that can be safely administered to humans and that accelerate the metabolism of cocaine to inactive components. Catalytic antibodies have been developed and shown to accelerate cocaine metabolism, but their catalytic efficiency for cocaine is relatively low. Mutations of human butyrylcholinesterase and a bacterial cocaine esterase found in the soil of coca plants have also been developed. These compounds accelerate cocaine metabolism and antagonize the behavioral and toxic effects of cocaine in animal models. Of these two approaches, the human butyrylcholinesterase mutants show the most immediate promise as they would not be expected to evoke an immune response in humans.
Affiliation :
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore, MD, USA