Historique
Article de Périodique
Molecular basis of long-term plasticity underlying addiction (2001)
Auteur(s) :
NESTLER, E. J.
Année
2001
Page(s) :
119-128
Langue(s) :
Anglais
Refs biblio. :
91
Domaine :
Plusieurs produits / Several products
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ADDICTION
;
NEUROBIOLOGIE
;
MECANISME D'ACTION
;
CERVEAU
;
GENETIQUE
;
NEUROTRANSMETTEURS
;
NEURONE
;
SYNAPSE
Résumé :
Studies of human addicts and behavioural studies in rodent models of addiction indicate that key behavioural abnormalities associated with addiction are extremely long lived. So, chronic drug exposure causes stable changes in the brain at the molecular and cellular levels that underlie these behavioural abnormalities. There has been considerable progress in identifying the mechanisms that contribute to long-lived neural and behavioural plasticity related to addiction, including drug-induced changes in gene transcription, in RNA and protein processing, and in synaptic structure. Although the specific changes identified so far are not sufficiently long lasting to account for the nearly permanent changes in behaviour associated with addiction, recent work has pointed to the types of mechanism that could be involved.
Affiliation :
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA