Historique
Article de Périodique
Vaccines against drug abuse (2012)
Auteur(s) :
SHEN, X. Y. ;
ORSON, F. M. ;
KOSTEN, T. R.
Année
2012
Page(s) :
60-70
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
90
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
VACCINATION
;
TRAITEMENT
;
ETHIQUE
;
MECANISME D'ACTION
;
COCAINE
;
ETUDE CLINIQUE
;
NICOTINE
;
METHAMPHETAMINE
;
OPIACES
Résumé :
The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are undergoing clinical trials (for cocaine and nicotine addiction) and two that are still in preclinical development (for methamphetamine and heroin addiction). We also outline the challenges and ethical concerns associated with the development of anti-addiction vaccines and their use as future therapeutics.
Affiliation :
Immunology Allergy & Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA