Historique
Article de Périodique
A systematic review and meta-analysis of interventions to prevent hepatitis C virus infection in people who inject drugs (2011)
(Revue systématique des interventions de prévention d'infection de l'hépatite C chez les personnes qui injectent des drogues)
Auteur(s) :
HAGAN, H. ;
POUGET, E. R. ;
DES JARLAIS, D. C.
Année
2011
Page(s) :
74-83
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
62
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
HEPATITE
;
USAGER
;
REDUCTION DES RISQUES ET DES DOMMAGES
;
INJECTION
;
INTERVENTION
;
EFFICACITE
;
TRAITEMENT
Thésaurus géographique
INTERNATIONAL
Résumé :
FRANÇAIS :
Dans le monde entier, les usagers de drogues sont victimes de taux élevés de transmission de l'hépatite C. Ce rapport analyse l'impact des interventions de réduction de risques sur la séro-conversion du virus de l'hépatite C et identifie les types d'interventions les plus efficaces.
ENGLISH:
INTRODUCTION: High rates of hepatitis C virus (HCV) transmission are found in samples of people who inject drugs (PWID) throughout the world. The objective of this paper was to meta-analyze the effects of risk-reduction interventions on HCV seroconversion and identify the most effective intervention types.
METHODS: We performed a systematic review and meta-analysis of published and unpublished studies. Eligible studies reported on the association between participation in interventions intended to reduce unsafe drug injection and HCV seroconversion in samples of PWID.
RESULTS: The meta-analysis included 26 eligible studies of behavioral interventions, substance-use treatment, syringe access, syringe disinfection, and multicomponent interventions. Interventions using multiple combined strategies reduced risk of seroconversion by 75% (pooled relative risk, .25; 95% confidence interval, .07-.83). Effects of single-method interventions ranged from .6 to 1.6.
CONCLUSIONS: Interventions using strategies that combined substance-use treatment and support for safe injection were most effective at reducing HCV seroconversion. Determining the effective dose and combination of interventions for specific subgroups of PWID is a research priority. However, our meta-analysis shows that HCV infection can be prevented in PWID.
Dans le monde entier, les usagers de drogues sont victimes de taux élevés de transmission de l'hépatite C. Ce rapport analyse l'impact des interventions de réduction de risques sur la séro-conversion du virus de l'hépatite C et identifie les types d'interventions les plus efficaces.
ENGLISH:
INTRODUCTION: High rates of hepatitis C virus (HCV) transmission are found in samples of people who inject drugs (PWID) throughout the world. The objective of this paper was to meta-analyze the effects of risk-reduction interventions on HCV seroconversion and identify the most effective intervention types.
METHODS: We performed a systematic review and meta-analysis of published and unpublished studies. Eligible studies reported on the association between participation in interventions intended to reduce unsafe drug injection and HCV seroconversion in samples of PWID.
RESULTS: The meta-analysis included 26 eligible studies of behavioral interventions, substance-use treatment, syringe access, syringe disinfection, and multicomponent interventions. Interventions using multiple combined strategies reduced risk of seroconversion by 75% (pooled relative risk, .25; 95% confidence interval, .07-.83). Effects of single-method interventions ranged from .6 to 1.6.
CONCLUSIONS: Interventions using strategies that combined substance-use treatment and support for safe injection were most effective at reducing HCV seroconversion. Determining the effective dose and combination of interventions for specific subgroups of PWID is a research priority. However, our meta-analysis shows that HCV infection can be prevented in PWID.
Affiliation :
New York University College of Nursing, NY, USA