Historique
Périodique
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs
(Un analogue de la cocaïne couplé à un adenovirus inactivé : une stratégie vaccinale qui suscite une immunité plus élevée contre les drogues addictives)
Auteur(s) :
HICKS, M. J. ;
DE, B. P. ;
ROSENBERG, J. B. ;
DAVIDSON, J. T. ;
MORENO, A. Y. ;
JANDA, K. D. ;
WEE, S. ;
KOOB, G. F. ;
HACKETT, N. R. ;
KAMINSKY, S. M. ;
WORGALL, S. ;
TOTH, M. ;
MEZEY, J. G. ;
CRYSTAL, R. G.
Année
2011
Page(s) :
612-619
Langue(s) :
Anglais
ISBN :
1525-0016
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Molecular Therapy, 2011, Vol. 19, n°3, p.612-619
Résumé :
Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1−E3− adenovirus (Ad) gene transfer vectors are potent immunogens, we have developed a novel vaccine platform for addictive drugs by covalently linking a cocaine analog to the capsid proteins of noninfectious, disrupted Ad vector. The Ad-based anticocaine vaccine evokes high-titer anticocaine antibodies in mice sufficient to completely reverse, on a persistent basis, the hyperlocomotor activity induced by intravenous administration of cocaine.
Affiliation :
Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA
Cote :
A02336