Historique
Article de Périodique
Proficiency testing (external quality assessment) of drug detection in oral fluid (2005)
Auteur(s) :
CLARKE, J. ;
WILSON, J. F.
Année
2005
Page(s) :
161-164
Langue(s) :
Anglais
Refs biblio. :
8
Domaine :
Plusieurs produits / Several products
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TEST
;
SENSIBILITE
;
SALIVE
;
DEPISTAGE
;
AMPHETAMINE
;
CANNABIS
;
OPIACES
;
METHODE
;
PSYCHOTROPES
;
ANALYSE CHIMIQUE
Résumé :
Eighteen external quality assessment (proficiency testing) samples were prepared from client specimens collected with the Intercept oral fluid collection device and by spiking drug-free oral fluid. Samples were circulated in pairs at quarterly intervals to 13 UK and USA based laboratories for analysis by a panel of OraSure micro-plate Intercept enzyme immunoassay kits and hyphenated mass spectrophotometric techniques. During the survey, there was a single case of non-specificity in a false report for methadone. The major errors were of lack of sensitivity relative to the concentration thresholds specified for the immunoassays. The sensitivity for overall "present"/"not found" reports calculated as true positives/(true positives+false negatives) were for the amphetamine specific assay 50%, methyl-amphetamines 93%, barbiturates 64%, cannabinoids 73%, cocaine and metabolites 100%, benzodiazepines 69%, methadone 95%, opiates 79% (opiates excluding oxycodone 93%), phencyclidine 93% and human gamma-globulin 97%. A small number of the sensitivity errors were attributable to errors in chromatographic confirmation techniques.
Affiliation :
Altrix Healthcare plc, Birchwood Science Park, Warrington WA3 7BP. Royaume-Uni. United Kingdom.
Cote :
R00164