Historique
Article de Périodique
Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis (2010)
Auteur(s) :
CLEARY, B. J. ;
DONNELLY, J. ;
STRAWBRIDGE, J. ;
GALLAGHER, P. J. ;
FAHEY, T. ;
CLARKE, M. ;
MURPHY, D. J.
Année
2010
Page(s) :
2071-2084
Sous-type de document :
Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
105
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
GROSSESSE
;
SUBSTITUTION
;
NOUVEAU-NE
;
SYNDROME DE SEVRAGE
;
METHADONE
;
TRAITEMENT DE MAINTENANCE
Résumé :
AIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy. [Author's abstract]
Affiliation :
Coombe Women and Infants University Hospital, Dublin 8, Ireland School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland / Irlande