Historique
Article de Périodique
Buprenorphine-based regimens and methadone for the medical management of opioid dependence: selecting the appropriate drug for treatment (2010)
Auteur(s) :
MAREMMANI, I. ;
GERRA, G.
Année
2010
Page(s) :
557-568
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
71
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
TRAITEMENT DE MAINTENANCE
;
EFFICACITE
;
SUBSTITUTION
;
BUPRENORPHINE
;
METHADONE
;
COMPARAISON
;
PERCEPTION
;
SURDOSE
;
EFFET SECONDAIRE
Résumé :
Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms. The perception that methadone is more effective than buprenorphine for maintenance treatment has been based on low buprenorphine doses and excessively slow induction regimens used in early buprenorphine trials. Subsequent studies show that the efficacy of buprenorphine sublingual tablet (Subutex(R)) or buprenorphine/naloxone sublingual tablet (Suboxone(R)) is equivalent to that of methadone when sufficient buprenorphine doses, rapid induction, and flexible dosing are used. Although methadone remains an essential maintenance therapy option, buprenorphine-based regimens increase access to care and provide safer, more appropriate treatment than methadone for some patients. [Author's abstract]
Affiliation :
Vincent P. Dole Dual Diagnosis Unit, Department of Psychiatry, NPB, Santa Chiara University Hospital, University of Pisa, Pisa, Italy / Italie