Historique
Périodique
Buprenorphine treatment of opioid dependence: a review
(Traitement à la buprénorphine de la dépendance aux opiacés : revue de la littérature)
Auteur(s) :
BICKEL, W. K. ;
AMASS, L.
Année
1995
Page(s) :
477-489
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Français
Refs biblio. :
110
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
BUPRENORPHINE
;
OPIOIDES
;
SUBSTITUTION
;
TRAITEMENT DE MAINTENANCE
Thésaurus géographique
ETATS-UNIS
Note générale :
Experimental and Clinical Psychopharmacology, 1995, 3, (4), 477-489
Note de contenu :
tabl.
Résumé :
ENGLISH :
Buprenorphine, a partial mu-agonist opioid, is a promising pharmacotherapy for the treatment of opioid dependence. One hundred and eight papers are organized according to 3 components essential to buprenorphine's use as a pharmacotherapy for opioid dependence: inducting patients onto buprenorphine, maintaining patients on buprenorphine, and discontinuing patients from buprenorphine treatment. The research suggests that inducting patients onto buprenorphine should lead to limited discomfort if appropriate procedures are followed. As a maintenance treatment, buprenorphine is as efficacious as methadone, blocks the effects of exogenously administered opioids, promotes treatment compliance, and, importantly, can support an alternate-day dosing regimen by doubling the daily dose. Discontinuing buprenorphine treatment appears to result in a mild-to-moderate opioid withdrawal syndrome that is less severe than that observed with full-efficacy agonists. (Review' s abstract)
Affiliation :
Human Behavioral Pharmacology Lab., Dpt of Psychiatry, Univ. of Vermont, 38 Fletcher Plce, Ira Allen School, Burlington, Vermont 05401-1419
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A00461