Historique
Périodique
Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice
Auteur(s) :
DALTERIO S. ;
BARTKE, A. ;
MAYFIELD D.
Année
1981
Page(s) :
581-583
Langue(s) :
Anglais
Refs biblio. :
17
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TETRAHYDROCANNABINOL
;
MODELE ANIMAL
;
EFFET SECONDAIRE
;
VOIE ORALE
;
SEXUALITE
;
SANG
Thésaurus géographique
ETATS-UNIS
Note générale :
Science, 1981, 213, (4507), 581-583
Résumé :
ENGLISH :
Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses. In hypophysectomized and intact mice receiving gonadotropins (human chorionic gonadotropin), treatment with delta 9-tetrahydrocannabinol maintained higher plasma testosterone concentrations. Thus, this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.
Affiliation :
Departments of Pharmacology and Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A01014