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The association of hepatitis C prevalence, activity and genotype with HIV infection in a cohort of New York city drug users
(Association de la prévalence, de l'activité et du génotype de l'hépatite C avec l'infection au VIH dans une cohorte d'usagers de drogues de la ville de New York)
Auteur(s) :
STRASFELD L. ;
LO, Y. ;
NETSKI D. ;
THOMAS, D. L. ;
KLEIN, R. S.
Année
2003
Page(s) :
356-364
Langue(s) :
Anglais
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
EPIDEMIOLOGIE DESCRIPTIVE
;
PREVALENCE
;
HEPATITE
;
VIH
;
INFECTION
;
USAGER
;
VOIE NASALE
;
VOIE INTRAVEINEUSE
Thésaurus géographique
ETATS-UNIS
Note générale :
Journal of Acquired Immune Deficiency Syndromes, 2003, 33, (3), 356-364
Résumé :
Factors associated with serum HCV antibody, HCV RNA level, and HCV genotype were assessed in 557 current and former drug users. Additional assays included HIV antibody, CD4+ lymphocyte counts, HIV viral loads, and hepatitis B markers. Seventy-five percent of subjects were anti-HCV positive, of whom 75% had detectable HCV RNA (median, 5.04 x 10(5) IU/mL; range, 1020-15.7 x 10(6)). On multivariate analysis HCV seropositivity was associated with history of drug injection, HIV seropositivity, and increased age and inversely with drug snorting. Among anti-HCV-positive persons, detectable HCV RNA was independently associated with HIV seropositivity, male gender, and history of injection and inversely associated with hepatitis B surface antigen positivity. Among persons with detectable HCV RNA, higher levels were independently associated with higher HIV viral load, increased age, and genotypes 2a and 2b. These findings demonstrate an association of HCV RNA level with HIV viral load, independent of the level of immunosuppression. However, a substantial degree of the person-to-person variability in the prevalence and level of detectable HCV RNA remains unexplained.
Affiliation :
Montefiore Medical Cter, 111 East 210th Str., Bronx, New York, NY 10467
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A01436