Historique
Périodique
Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependence
(Etude pilote non masquée de Bupropion ajouté à de la bromocryptine pour le traitement de la dépendance à la cocaïne)
Auteur(s) :
MONTOYA, I. D. ;
PRESTON, K. L. ;
ROTHMAN, R. ;
GORELICK, D. A.
Année
2002
Page(s) :
189-196
Langue(s) :
Français
Refs biblio. :
13
Domaine :
Drogues illicites / Illicit drugs
Note générale :
American Journal of Drug and Alcohol Abuse, 2002, 28, (1), 189-196
Note de contenu :
tabl.
Résumé :
ENGLISH :
Combinations of medications are often used in neuropsychiatry to enhance treatment efficacy. This 8-week, open-label study tested the combination of bupropion (< or =300 mg) and bromocriptine (< or =7.5 mg) daily in 34 cocaine-dependent (DSM-IIIR) outpatients also receiving weekly individual counseling. The first 18 subjects spent one week at maximum dose; the next 16 spent three weeks. Both groups showed significant reductions in self-reported cocaine use, with no significant change in proportion of urine toxicology tests positive for cocaine. There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy. (Review' s abstract)
Affiliation :
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
AJDA