Historique
Article de Périodique
Transferring methadone-maintained outpatients to the buprenorphine sublingual tablet: a preliminary study (2003)
(Transferrer des patients en traitement ambulatoire à la méthadone vers un traitement à la buprénorphine sublinguale : une étude préliminaire.)
Auteur(s) :
GREENWALD, M. K. ;
SCHUH, K. J. ;
STINE, S. M.
Année
2003
Page(s) :
365-374
Langue(s) :
Anglais
Refs biblio. :
72
Domaine :
Drogues illicites / Illicit drugs
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
METHADONE
;
BUPRENORPHINE
;
OPIACES
;
OBSERVANCE DU TRAITEMENT
;
PHARMACIE
;
PRISE EN CHARGE
;
MESUSAGE
;
MORPHINE
;
BENZODIAZEPINES
;
REDUCTION DES RISQUES ET DES DOMMAGES
;
LEGISLATION
;
POLYCONSOMMATION
;
MEDECIN GENERALISTE
;
INJECTION
;
ENQUETE
;
ETUDE DE CAS
;
EVOLUTION
Note générale :
American Journal on Addictions, 2003, 12, (4), 365-374
Résumé :
There is no accepted algorithm to transfer opioid-dependent patients from methadone (METH) to its new alternative, buprenorphine (BUP). Five outpatients transferred (double blind, double dummy) from METH 60 mg/day (with one day at 45 mg) to BUP 8 mg s.l. tablet. Relative to METH maintenance, BUP decreased opioid agonist symptoms (transfer day 1) and increased withdrawal symptoms (days 1 and 2) and blood pressure (day 2). Self-reported heroin use did not increase from METH maintenance levels. It may be feasible to transfer outpatients on METH 60 mg/day to BUP 8 mg/day s.l. tablet, although this pilot protocol needs refinements to improve tolerability and clinical efficacy. [Author's abstract]
Affiliation :
Substance Abuse Res. Div., Dept Psychiatry Behav. Neurosci., Wayne State Univ. School Med., 2761 East Jefferson Ave., Detroit, MI 48207, United States