Historique
Article de Périodique
Pharmacology: uncoupling the agony from ecstasy. A mitochondrial protein may mediate a dangerous side-effect of some recreational drugs (2003)
(Pharmacologie : dissocier douleur et ecstasy. Une protéine mitochondriale pourrait modérer un effet secondaire dangereux de certaines drogues récréatives)
Auteur(s) :
MILLS, E. M. ;
BANKS, M. L. ;
SPRAGUE J. E. ;
FINKEL, T.
Année
2003
Page(s) :
403-404
Langue(s) :
Anglais
Refs biblio. :
9
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
MDMA-ECSTASY
;
EFFET SECONDAIRE
;
PROTIDES
;
HYPERTHERMIE
;
MODELE ANIMAL
;
PHARMACOLOGIE
Résumé :
The recreational use of amphetamine-type stimulants can produce a marked and sometimes lethal increase in body temperature. Here we show that mice deficient in a mitochondrial protein known as UCP-3 (for 'uncoupling protein-3') have a diminished thermogenic response to the drug MDMA (3,4-methylenedioxymethamphetamine, nicknamed 'ecstasy') and so are protected against this dangerously toxic effect. Our findings indicate that UCP-3 is important in MDMA-induced hyperthermia and point to a new therapeutic direction for solving an increasing public-health problem.
Affiliation :
Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland, USA