Historique
Article de Périodique
Molecular and cellular basis of addiction (1997)
(Fondements moléculaires et cellulaires de l'addiction)
Auteur(s) :
NESTLER, E. J. ;
AGHAJANIAN, G. K.
Année
1997
Page(s) :
58-63
Langue(s) :
Anglais
Refs biblio. :
63
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
DEPENDANCE
;
NEUROBIOLOGIE
;
ADAPTATION
;
RECEPTEUR
;
MECANISME D'ACTION
;
ADDICTION
Résumé :
FRANÇAIS :
La toxicomanie résulte d'adaptations spécifiques des neurones, provoquée par des expositions successives aux drogues. Ces adaptations entrainent des comportements complexes qui conduisent au stade de dépendance. La recherche progresse dans la définition de ces adaptations en fonction du temps et du produit. Il s'agit de comprendre quel type d'adaptation correspond aux différents aspects de l'addiction tel que le manque ou la rechute, et d'identifier les gènes spécifiques qui entrainent les variations de sensibilité individuelles.
ENGLISH :
Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted state. Progress is being made in identifying such time-dependent, drug-induced adaptations and relating them to specific behavioral features of addiction. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction, such as drug craving and relapse, and to identify specific genes that contribute to individual differences in vulnerability to addiction. Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated.
La toxicomanie résulte d'adaptations spécifiques des neurones, provoquée par des expositions successives aux drogues. Ces adaptations entrainent des comportements complexes qui conduisent au stade de dépendance. La recherche progresse dans la définition de ces adaptations en fonction du temps et du produit. Il s'agit de comprendre quel type d'adaptation correspond aux différents aspects de l'addiction tel que le manque ou la rechute, et d'identifier les gènes spécifiques qui entrainent les variations de sensibilité individuelles.
ENGLISH :
Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted state. Progress is being made in identifying such time-dependent, drug-induced adaptations and relating them to specific behavioral features of addiction. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction, such as drug craving and relapse, and to identify specific genes that contribute to individual differences in vulnerability to addiction. Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated.
Affiliation :
Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT, USA