Historique
Article de Périodique
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism (1997)
Auteur(s) :
TANDA G. ;
PONTIERI, F. E. ;
DI CHIARA G.
Année
1997
Page(s) :
2048-2050
Langue(s) :
Anglais
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
NEUROBIOLOGIE
;
PHARMACOLOGIE
;
CANNABINOIDES
;
TETRAHYDROCANNABINOL
;
HEROINE
;
DOPAMINE
;
RECEPTEUR
;
ANTAGONISTE
;
MODELE ANIMAL
Résumé :
The effects of the active ingredient of Cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), and of the highly addictive drug heroin on in vivo dopamine transmission in the nucleus accumbens were compared in Sprague-Dawley rats by brain microdialysis. Delta9-THC and heroin increased extracellular dopamine concentrations selectively in the shell of the nucleus accumbens; these effects were mimicked by the synthetic cannabinoid agonist WIN55212-2. SR141716A, an antagonist of central cannabinoid receptors, prevented the effects of Delta9-THC but not those of heroin. Naloxone, a generic opioid antagonist, administered systemically, or naloxonazine, an antagonist of micro1 opioid receptors, infused into the ventral tegmentum, prevented the action of cannabinoids and heroin on dopamine transmission. Thus, Delta9-THC and heroin exert similar effects on mesolimbic dopamine transmission through a common mu1 opioid receptor mechanism located in the ventral mesencephalic tegmentum.
Affiliation :
Dpt of Toxicology and Consiglio Nazionale delle Ricerche (CNR), Center for Neuropharmacology, Univ. of Cagliari, Cagliari, Italy