Historique
Périodique
Transition from moderate to excessive drug intake: change in hedonic set point
(Passage d'une prise de drogue modérée vers une consommation excessive)
Auteur(s) :
AHMED, S. H. ;
KOOB, G. F.
Année
1998
Page(s) :
298-300
Langue(s) :
Français
Refs biblio. :
15
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
MODELE ANIMAL
;
AUTOADMINISTRATION
;
COCAINE
;
DOSE-REPONSE
;
USAGE REGULIER
;
ABUS
;
THEORIE DE L'ESCALADE
Note générale :
Science, 1998, 282, (5387), 298-300
Note de contenu :
graph.
Résumé :
ENGLISH :
Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction. (Review' s abstract)
Affiliation :
Division of Psychopharmacology, Dpt of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A01791