Historique
Périodique
Discriminative-stimulus effects of modafinil in cocaine-trained humans
(Effet de stimulus discriminatoire du modafinil chez des usagers de cocaïne)
Auteur(s) :
RUSH, C. R. ;
KELLY, T. H. ;
HAYS, L. R. ;
WOOTEN, A. F.
Année
2002
Page(s) :
311-322
Langue(s) :
Anglais
Refs biblio. :
54
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
TRAITEMENT
;
STIMULANTS
;
MECANISME D'ACTION
;
COMPARAISON
;
ESSAI THERAPEUTIQUE
;
MODAFINIL
Note générale :
Drug and Alcohol Dependence, 2002, 67, (3), 311-322 ; fig.
Résumé :
Modafinil is a novel stimulant that is effective in the treatment of narcolepsy and excessive daytime sleepiness. In vitro and in vivo neuropharmacological data suggest that the mechanism of action of modafinil is distinct from that of prototypical abused stimulants like cocaine and d-amphetamine. In the present experiment, six human volunteers with recent histories of cocaine use learned to discriminate 150 mg oral cocaine HCL. After acquiring the discrimination (i.e. > 80% correct responding on 4 consecutive days), a range of doses of oral cocaine (50, 100, and 150 mg), modafnil (200, 400, and 600 mg), and placebo were tested to determine if they shared discriminative-stimulus and self reported effects with 150 mg cocaine. Methylphenidate (60 mg) and triazolam (0.5 mg) were included as positive and negative controls, respectively. Cocaine and methylphenidate, but neither modafinil nor triazolam, produced cocaine-like discriminative-stimulus, subject-rated, and cardiovascular effects. The results of the present experiment suggest that cocaine discrimination in humans is pharmacologically specific within and across drug classes. (Review's abstract.)
Affiliation :
Dept. Behav. Sci., Univ. KY, Lexington, KY 40536-0086
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A01906