Historique
Périodique
Differences in the incidence of hepatitis B and human immuniodeficiency virus infections among injecting drug users
Auteur(s) :
LEVINE, O. ;
VLAHOV, D. ;
BROOKMEYER R. ;
COHN, S. ;
NELSON, K. E.
Année
1996
Page(s) :
579-583
Langue(s) :
Anglais
Refs biblio. :
21
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Note générale :
Journal of Infectious Diseases, 1996, (173), 579-583
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Both hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 seroconversions have been considered as outcome measures to evaluate the effectiveness of needle exchange programs. To assess the relationships between incident HBV and HIV infections among injecting drug users (IDUs), seroconversions were prospectively studied among a cohort of 240 HBV- and HIV- seronegative IDUs. The incidence of HBV seroconversion declined from 24.41/100 person-years in 1988 to 0 seroconversions in 1992. In contrast, HIV seroconversion rates varied little from the overall rate of 3.29/100 person-years. HBV seroconversion predicted subsequent HIV seroconversion among male IDUs (relative incidence [RI]= 4.23) but not among female IDUs (RI=0.86). Because of different transmission dynamics, HBV seroconversion probably has limited utility as a surrogate outcome measure for incident HIV. However, HBV seroconversion itself is an appropriate and important outcome measure for evaluation of prevention programs among IDUs.
Affiliation :
Etats-Unis. United States.
Cote :
A01998