Historique
Périodique
Patterns of methamphetamine abuse and their consequences
(Types d'usage et conséquences de l'abus de métamphétamines.)
Auteur(s) :
CHO, A. K. ;
MELEGA W. P.
Année
2002
Page(s) :
21-34
Langue(s) :
Français
Refs biblio. :
64
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
METHAMPHETAMINE
;
PHARMACOLOGIE
;
PHARMACOCINETIQUE
;
EFFET SECONDAIRE
;
USAGE REGULIER
;
TOLERANCE
;
TOXICITE
Note générale :
Journal of Addictive Diseases, 2002, 21, (1), 21-34
Note de contenu :
fig.
Résumé :
ENGLISH :
The abuse of methamphetamine (METH) continues to increase throughout all age groups in different regions of the United States. "Ice," the popularized jargon for (+) methamphetamine hydrochloride, is the predominant drug form that is now consumed. "Ice" is effectively absorbed after either smoking or snorting and it is this rapid influx of drug that produces effects similar to those after intravenous administration. The intensity of METH actions in the central and peripheral nervous system shows tolerance after chronic administration, indicating that neuro-adaptations have occurred. Thus, the physiological processes and corresponding biochemical mechanisms that regulate neuronal function have been changed by METH exposure. These biological alterations contribute to the craving and dependence associated with METH abuse and the withdrawal syndrome upon abstinence. However, these changes in behavior may also result from METH-induced neurotoxicity. This article reviews aspects of METH pharmacokinetics and related molecular pharmacodynamics that represent METH pharmacology and then relates those actions to their potential to produce neurotoxicity in humans. (Editor' s abstract)
Affiliation :
Dep. Molecular and medical pharmacology, 23-120 CHS, UCLA School Med., Box 951735, Los Angeles, CA 90095-1735
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A02107