Historique
Article de Périodique
Review: Pharmacokinetics of illicit drugs in oral fluid (2005)
(Revue : Pharmacocinétique des drogues illicites dans la salive)
Auteur(s) :
DRUMMER, O. H.
Année
2005
Page(s) :
133-142
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
40
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
SALIVE
;
PRODUIT ILLICITE
;
DEPISTAGE
;
PHARMACOCINETIQUE
;
METHODE
;
MESURES QUANTITATIVES
Résumé :
This article reviews studies that have measured drug concentrations in oral fluid following controlled dosing regimens. A total of 23 studies have been identified over the last 15 years. These show that the amphetamines including designer amphetamines, cocaine, cannabis and cocaine are quickly found in oral fluid following dosing and usually have similar time-courses to that in plasma. Following common doses peak oral fluid concentrations exceed 0.1 ug/mL and often even 1 ug/mL. The drug concentration will depend on whether a dilution step occurs with buffer as part of the sampling procedure. The uses of collectors that stimulate oral fluid usually reduce the drug concentration compared to a non-stimulated manner. This reduction will not disadvantage the recipient since it will potentially reduce the detectability of drug in oral fluid compared to non-stimulated collections. Only one recent study has been reported for a benzodiazepine. This showed nanogram per milliliter concentrations for flunitrazepam. More studies are required for benzodiazepines and indeed for other drugs, particularly in multiple drug situations and where disease may affect the pharmacokinetics of drugs. (Author' s abstract)
Affiliation :
Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, 57-83 Kavanagh Street, Southbank, Melbourne 3006.
Australie. Australia.
Australie. Australia.
Cote :
R00164