Historique
Article de Périodique
Addiction: a disease of learning and memory (2005)
Auteur(s) :
HYMAN, S. E.
Année
2005
Page(s) :
1414-1422
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
99
Domaine :
Plusieurs produits / Several products
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
MEMOIRE
;
DEPENDANCE
;
NEUROBIOLOGIE
;
APPRENTISSAGE
;
TROUBLES DE LA MEMOIRE
;
DOPAMINE
;
CERVEAU
Résumé :
If neurobiology is ultimately to contribute to the development of successful treatments for drug addiction, researchers must discover the molecular mechanisms by which drug-seeking behaviors are consolidated into compulsive use, the mechanisms that underlie the long persistence of relapse risk, and the mechanisms by which drug-associated cues come to control behavior. Evidence at the molecular, cellular, systems, behavioral, and computational levels of analysis is converging to suggest the view that addiction represents a pathological usurpation of the neural mechanisms of learning and memory that under normal circumstances serve to shape survival behaviors related to the pursuit of rewards and the cues that predict them. The author summarizes the converging evidence in this area and highlights key questions that remain. (Author' s abstract)
Affiliation :
Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Cote :
A02345