Historique
Périodique
The impact of barriers to hepatitis C virus treatment in recovering heroin users maintained on methadone
Auteur(s) :
SYLVESTRE, D. L. ;
LITWIN, A. H. ;
CLEMENTS, B. J. ;
GOUREVITCH, M. N.
Année
2005
Page(s) :
159-165
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
HEPATITE
;
HEROINE
;
TRAITEMENT
;
METHADONE
;
TRAITEMENT DE MAINTENANCE
;
GUERISON
;
ANTIVIRAUX
Thésaurus géographique
ETATS-UNIS
Note générale :
Journal of Substance Abuse Treatment, 2005, 29, (3), 159-165
Résumé :
ENGLISH :
Although most cases of hepatitis C virus (HCV) infection are associated with injection drug use, there are few data regarding the impact of putative barriers such as psychiatric disease and intercurrent drug use on HCV treatment outcomes. To define the impact of characteristics often cited as reasons for withholding HCV treatment, we studied HCV treatment in a real world sample of 76 recovering heroin users maintained on methadone. Overall, 21 (28%) had a sustained virological response and 18 (24%) discontinued treatment early. Although there was a modest decrement in response rates in patients reporting a preexisting psychiatric history (p = .01), neither intercurrent drug use nor short duration of pretreatment drug abstinence led to significant reductions in virological outcomes (p = .09 and p = .18, respectively.) We conclude that injection drug users can be safely and effectively treated for HCV despite multiple barriers to treatment when they are treated in a setting that can address their special needs.
Affiliation :
Department of Medicine, University of California, San Francisco, CA. Email : dsylves@itsa.ucsf.edu
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A02477