Historique
Article de Périodique
Obviation of opioid withdrawal syndrome by concomitant administration of Naltrexone in microgram doses : two psychonautic bioassays (2006)
(Antidote au syndrome de sevrage lié aux opiacés, grâce à une administration simultanée de quelques milligrammes de Naltrexone : deux recherches sur l'auto-expérimentation de substances psychoactives)
Auteur(s) :
OTT, J.
Année
2006
Page(s) :
101-105
Langue(s) :
Anglais
Refs biblio. :
11
Domaine :
Drogues illicites / Illicit drugs
Thésaurus géographique
SUISSE
Thésaurus mots-clés
SYNDROME DE SEVRAGE
;
OPIACES
;
NALTREXONE
;
MESURES QUANTITATIVES
;
CODEINE
;
TRAITEMENT
;
ENQUETE
;
TOLERANCE
;
DEPENDANCE
;
ETUDE DE CAS
Note générale :
Journal of Psychoactive Drugs, 2006, 38, (1), 101-105
Cf. http://www.entheogen.com/forum/archive/index.php?t-2784.html pour la définition par l'auteur de la notion de "psychonautic bioassay".
Cf. http://www.entheogen.com/forum/archive/index.php?t-2784.html pour la définition par l'auteur de la notion de "psychonautic bioassay".
Note de contenu :
tabl.
Résumé :
ENGLISH :
Two psychonautic bioassays (self-experiments) in stepwise and abrupt cessation of long-term daily oral ingestion habits of 800 mg of codeine phosphate are presented. Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism. These experiments are analyzed in the context of a conjectured, rapid, iterative reduction and complete elimination of opioid tolerance, once acquired. It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.
Affiliation :
Entheobotanica, Solothum
Suisse. Switzerland.
Suisse. Switzerland.
Cote :
Abonnement