Historique
Périodique
Evidence of cocaine-related coronary atherosclerosis in young patients with myocardial infarction. (Letter to the Editor)
(Mise en évidence de l'athérosclérose coronaire liée à la cocaïne chez des patients jeunes ayant subi un infarctus du myocarde)
Auteur(s) :
PATRIZI, R. ;
PASCERI, V. ;
SCIAHBASI, A. ;
SUMMARIA, F. ;
ROSANO, G. M. ;
LIOY, E.
Année
2006
Page(s) :
2120-2122
Langue(s) :
Anglais
Refs biblio. :
8
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Note générale :
Journal of the American College of Cardiology, 2006, 47, (10), 2120-2122
Résumé :
Cocaine use has increased in the last years reaching in 1999 in the U.S. 30% of all drug-related visits to the emergency department, exceeding morphine and representing the most frequent cause of drug-related deaths. One of every four myocardial infarctions (MIs) in people aged 18 to 45 years can be linked to cocaine use. Several reports implicated coronary vasospasm in normal coronary arteries as the cause of MI in cocaine users, but other studies revealed the cocaine-related enhanced vasoconstriction at the site of significant stenosis. Animal and experimental studies support the proatherosclerotic effects of cocaine; this drug may increase concentration of plasminogen-activator inhibitor, endothelial permeability to low-density lipoprotein, and platelet activation and aggregability. Moreover, post-mortem studies have suggested that signs of coronary atherosclerosis can be detected in cocaine users, despite the young age, but this observation can be influenced by survival bias. Thus, we studied the prevalence of coronary atherosclerosis in young patients suffering from acute MI with and without evidence of cocaine use. (Extract of the publication)
Affiliation :
Catheterization Laboratory, Department of Cardiology, Policlinico Casilino ASL Roma B, Via Lucio Elio Seiano 80 00174, Rome.
Italie. Italy.
Italie. Italy.
Cote :
A02731