Historique
Périodique
Risk of substance use disorders in adolescents with bipolar disorder
(Le risque de troubles liés à l'usage de substance chez des adolescents atteints de troubles bipolaires)
Auteur(s) :
WILENS, T. E. ;
BIEDERMAN, J. ;
KWON, A. ;
DITTERLINE, J. ;
FORKNER, P. ;
MOORE, H. ;
SWEZEY, A. ;
SNYDER, L. ;
HENIN, A. ;
WOZNIAK, J. ;
FARAONE, S. V.
Année
2004
Page(s) :
1380-1386
Langue(s) :
Anglais
Domaine :
Plusieurs produits / Several products
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
ADOLESCENT
;
TROUBLE BIPOLAIRE
;
COMPORTEMENT
;
PSYCHOSE MANIACO-DEPRESSIVE
;
PSYCHOPATHOLOGIE
;
FACTEUR DE RISQUE
;
COMORBIDITE
Thésaurus géographique
ETATS-UNIS
Note générale :
Journal of the American Academy of Child and Adolescent Psychiatry, 2004, 43, (11), 1380-1386
Résumé :
OBJECTIVE: Previous work in adults and youths has suggested that juvenile onset bipolar disorder (BPD) is associated with an elevated risk of substance use disorders (SUD). Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD. METHOD: Probands with DSM-IV BPD (n=57, mean age + SD=13.3 + 2.4 years) and without DSM-IV BPD (n=46, 13.6 + 2.2 years) were studied. Structured psychiatric interviews and multiple measures of SUD were collected. RESULTS: Bipolar disorder was associated with a highly significant risk factor for SUD (32% versus 7%, Z=2.9, p=.004) that was not accounted for by conduct disorder (adjusted odds ratio=5.4, p=.018). Adolescent-onset BPD (>=13 years) was associated with a higher risk of SUD compared with those with child-onset BPD (chi2(1)=9.3, p=.002). CONCLUSIONS: These findings strongly indicate that BPD, especially adolescent onset, is a significant risk factor for SUD independently of conduct disorder.
Affiliation :
Pediatric Psychopharmacology Unit, Child Psychiatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114.
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A02749