Historique
Périodique
Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm
Auteur(s) :
RAUPACH, T. ;
SCHAFER, K. ;
KONSTANTINIDES S. ;
ANDREAS, S.
Année
2006
Page(s) :
386-392
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Français
Refs biblio. :
126
Domaine :
Tabac / Tobacco / e-cigarette
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
TABAC
;
TABAGISME PASSIF
;
APPAREIL CARDIOVASCULAIRE
;
COEUR
;
ATHEROSCLEROSE
;
FACTEUR DE RISQUE
Note générale :
European Heart Journal, 2006, 27, (4), 386-392
+ Editorial : Protecting Europeans from secondhand smoke: time to act. F.K. Glantz & S.A. Glantz, p.382-383.
+ Editorial : Protecting Europeans from secondhand smoke: time to act. F.K. Glantz & S.A. Glantz, p.382-383.
Résumé :
ENGLISH :
The evidence that active smoking is a risk factor for cardiovascular disease (CVD) and the leading cause of preventable death is overwhelming. However, numerous epidemiological findings indicate that even passive exposure to cigarette smoke may exert detrimental effects on vascular homoeostasis. Recent experimental data provide a deeper insight into the pathophysiological mechanisms linking secondhand smoke (SHS) to CVD. Importantly, most of these effects appear to be characterized by a rapid onset. For example, the relatively low doses of toxins inhaled by passive smoking are sufficient to elicit acute endothelial dysfunction, and these effects may be related, at least in part, to the inactivation of nitric oxide. Moreover, passive smoking may directly impair the viability of endothelial cells and reduce the number and functional activity of circulating endothelial progenitor cells. In addition, platelets of non-smokers appear to be susceptible to pro-aggregatory changes with every passive smoke exposure. Overall, SHS induces oxidative stress and promotes vascular inflammation. Apart from vasoconstriction and thrombus formation, however, the myocardial oxygen balance is further impaired by SHS-induced adrenergic stimulation and autonomic dysfunction. These data strongly suggest that passive smoking is capable of precipitating acute manifestations of CVD (atherothrombosis) and may also have a negative impact on the outcome of patients who suffer acute coronary syndromes.
Affiliation :
Department of Cardiology and Pulmonology, University Clinic, Georg August University of Goettingen, D-37099 Goettingen. Email : skonstan@med.uni-goettingen.de
Allemagne. Germany.
Allemagne. Germany.
Cote :
A02808